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Simplification |
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The identification of proteins linked to causation of disease has proved difficult historically because of the relatively small number of high abundance proteins (HAPs) which comprise a very large percentage of any biological sample’s total protein mass. In total twenty HAPs represent >98% of the total protein mass, and combine to significantly inhibit the detection of low abundance proteins (LAPs) that may be associated with a physiological dysfunction. |
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The Multiple Affinity Removal System (MARS) reproducibly and specifically removes up to 14 human and 3 murine HAPs found in biological samples. Available in column format and convenient spin filters and concentrators for automated, integrated immunodepletion.
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Novel preparation tool which compresses the dynamic protein concentration range in complex biological samples. Large sample volumes can be processed, significantly increasing the opportunity for capture and detection of LAPs.
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