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Manufacturers > SiliCycle > Silica Bound Scavengers & Reagents > Microwave Assisted Scavenging |
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| SiliCycle - Microwave Assisted Scavenging |
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This rapidly growing field is highly compatible with silica bound scavengers and reagents. Below (table1) are the results using Si - Amine (Figure 1) to scavenge a variety of nucleophiles. The scavenging was carried out using 4 equiv under mircowave conditions: 4 min, 150°C, 300W. No leaching of the reactive groups was obeserved by GC-MS. The integrity of the functionalized silica gel under microwave conditions (700W, 30 min) is not affected. |
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| Nucleophile |
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% Scavenged |
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| Benzaldehyde |
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97 |
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| Benzoyl chloride |
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100 |
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| Acetic Anhydride |
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99 |
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| 1,1,3,3-Tetramethylbutylisocyanate |
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100 |
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| Tert-butylphenylisocyanate |
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100 |
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| Table 1: Nucleophile scavenging with Si- Amine under microwave conditions. Reactions were run by CEM corporation on a Discover™ synthesizer 4min, 150°C, 300W |
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Figure 1:
Si - Amine |
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