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Practical Dissolution Testing practical course
1 Day Course | GC Level 1

This one day course is an excellent introduction to the theory and principles of dissolution testing. This heavily regulated technique often appears simple to use, but the underlying theory and significance of the various apparatus and test methodologies is complex.

  • We limit numbers to 6 per course so that each delegate gets the opportunity to ask questions and fully participate in practical exercises
  • When delivered on-site we can design the course material to suit your specific training needs
  • Customisable written assessments are available if required

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on site Practical Dissolution Testing
on site
on site

A comprehensive one day practical course that condenses important theory with critical calibration, verification and practical tips; making it a must for anyone using dissolution equipment.

The course is backed with explanatory images and supplemented with a practical session with state of the art instruments.

Who is this course for

This course is for analysts or method developers who need to master dissolution testing in order to design and implement effective protocols, or comply with stringent regulations.

Previous knowledge

A basic knowledge of chemistry is advantageous. Previous experience using dissolution equipment will be beneficial.

What you will learn

  • The different regulatory approaches to dissolution testing
  • Dissolution rates and equilibria
  • Equipment calibration and maintenance
  • Performance verification and error investigation

Dissolution Testing in Context

  • USP dissolution: historical highlights
  • Current approaches: the ISO framework


Performance Verification Testing

  • Analytical Instrument Qualification and ISO Standards
  • Elements of routine maintenance
  • The Performance Verification test
  • Sources of errors

Dissolution Theory

  • Dissolution equations
  • Factors influencing dissolution rates
  • Significance of dissolution training

Putting it All Into Practice

  • Medium preparation and equipment set-up
  • Prednisone testing
  • Reviewing prednisone results

Training Calendar

Click on a title below to download a detailed course description or click a date and book your course.

Can't find a suitable training course? Call 01357 522 961 or email us.

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Ionic Interactions - Solubility

Ionic functional groups on analyte molecules are very different than hydrophobic or polar groups in that ionic group properties are a function of the charge state of the species. Therefore, the interactions of an ionic analyte with either a solvent or sorbent environment will similarly be influenced by the charge state.

From a solubility perspective, ionized groups tend to favor solubility in highly polar solvents. Therefore, bases at low pH (ionized) and acids at high pH (ionized) will be more soluble in highly aqueous solvents, including pure water, most buffers, and solutions containing water or buffers in combination with water-miscible organic solvents at relatively low concentration. (Acids)

Conversely, ionic groups in a neutral state tend to favor solubility in non-polar solvents. Therefore, bases at high pH (neutral) and acids at low pH (neutral) will be more soluble in more non-polar solvents such as acetonitrile, THF, ethyl acetate, chloroform, etc.(Bases)

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