Chromatography Consumables, Analytical Services and Chromatography / Mass Spectrometry Training from Crawford Scientific
   you’re in > Products > High Throughput Chemistry > Supported Reagents
  
 


The use of solid supported reagents and scavengers is an excellent way to expedite organic synthesis by simplifying the purification process. Standard purification procedures including chromatography, liquid-liquid extraction and crystallisation can be time-consuming and difficult to scale up. In many cases, supported reagents have distinct advantages over their solution-phase counterparts, the biggest one being the ability to use incompatible reagents, such as an acid and a base, simultaneously. Other advantages include the ability to do multiple transformations in a single pot, the immobilisation of toxic reagents and increased selectivity. They are suitable for use in batch reactions and in flow through applications.

SiliCycle is a pioneer in the development of such supported reagents and scavengers based on silica, the most common silica being the standard flash silica gel, 40-63 μm 60A. Other silicas based on different porosities, particle sizes and sphericity are also available.

The advantages of using functionalised silica compared to polymeric resins are:

  • Fast kinetics – Since the silica is surface functionalised, the rate of reaction is not controlled by the diffusion in and out of the polymer. Most of the SililCycle scavengers work in under an hour.
  • Solvent independent – Silica neither shrinks nor swells in any solvent and because it is end-capped, it will also not dissolve in any solvent. The scavenger does not dictate the solvent for your reaction.
  • Easy to use – Easy to weigh and handle since silica does not carry a static charge and is always free flowing. Its high density makes it suitable for small volume work. It does not require extensive washing for high recoveries and will not stick to glassware. Amenable to automation.
  • Thermally stable – Most SiliCycle products can withstand temperatures of over 200C and are suitable for use in microwave synthesisers. Much more microwave friendly than polymeric resins.
  • Scalable – Works on the microgram to the multi-ton scale
  • Flexible formats – Because it does not swell, silica gel can be packed into a variety of flow through formats such as HPLC columns, flash and SPE cartridges and 96 well plates.
  • Controlled loading – Consistent and accurate loading lot-to-lot.
 

SiliCycle catalog
To browse the full SiliCycle catalog including silica scavenger resins, flash cartridges and TLC plates please click on the link below.
  Click here to request a catalog or pricing
  Click here to view the Silica of the month
   
Further Information:
 

References
In this section you have access to published scientific papers detailing the advantages of SiliCycle resins compared to the conventional polymeric resins.

Click on any of the links below to view the PDF. (Requires Acrobat Reader, click to download)

   Si-TMA Chloride Product Data Sheet 79 KB
   Si-Carbonate. Paper from Organic Letters 70 KB
   Si-Amine Paper from Tetrahedron 130 KB
   Amide synthesis application 80 KB
   Microwave-Assisted Synthesis Utilizing Supported Reagents 70 KB
   ORGN 201 - Silica-based carbonate 12 KB


 
  
 
 ©Crawford Scientific 2008