As with all YMC silica based bonded phases, YMC-Pack Diol starts with a base silica support of exceptional purity. YMC manufacturing and quality control procedures ensure that the silica has a very low residual metal content. The silica purity greatly reduces non-specific sample adsorption, thereby providing excellent sample recovery.
The high surface area, together with the large number of available sites for interaction of the 1,2-dihydroxypropane ligands, provides high preparative loading.
YMC-Pack Diol GPC columns exhibit better performance characteristics than underivatised silica for size separations as the non-specific adsorptive sites have been eliminated. Diol is available in four porosities: 6, 12, 20 and 30 nm and thus it is suitable for separation or molecular weight determination of proteins with molecular weights of 10,000 to several hundred thousands.
YMC-Pack Diol packings can be cleaned repeatedly with methanol, or even water. When combined with the high mechanical strength of the pure base silica, this washability means that YMC-Pack Diol packings provide longer column life than underivatised silica.