YMC Analytical Columns: YMCbasic

alternative bonding approach to reduce peak tailing of basic pharmaceuticals
no need for ion pair reagents or amine modifiers
complementing selectivity to C8 and C18 materials

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YMCbasic	Specification
Particle size / µm	3;5
Pore size / nm	proprietary
Surface area / m2g-1	proprietary
Carbon content / %	8
Recommended pH range	2.0 - 7.5

General

YMC created in 1988, yet still having fully up-to-date technology, a new bonded phase for the separation of basic pharmaceuticals and similar compounds by bringing together a support containing neutral silanol groups, which have minimal interactions with acidic and basic compounds, and a novel bonded phase consisting of monomerically bonded alkyl chains. The proprietary derivatisation procedure for YMCbasic allows YMC to produce a material with controlled surface coverage, which shows excellent lot-to-lot reproducibility as a result of closely monitoring both the production of the silica support and the bonding process.

The resulting YMCbasic material shows a different hydrophobicity compared with C8 or C18 phases as shown in the diagram. In addition, it also represents an interesting alternative to short chain selectivities.

Hydrophobicity of YMCbasic versus YMC-Pack Octyl and YMC-Pack ODS-AM

Column: 250 x 4.6 mm Eluent: acetonitrile / water (75/25) Flow: 1.0 ml/min Detection: UV at 254 nm

Column care

The recommended pH range for YMCbasic is 2-7,5. Remove acids and buffer salts before storage. Store the column in methanol/water=70/30. Clogged inlet frits often can be cleaned by changing the flow direction or replacement.
For detailed information please refer to the “Column Care and Use Instructions” which are shipped with each analytical column.

YMCbasic

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