YMC offers a comprehensive range of laboratory scale glass columns tailored to meet the diverse needs of modern laboratories. Whether you're conducting medium-pressure liquid chromatography (MPLC), high-pressure tasks, or high-temperature separations, YMC has the perfect solution with its ECO, ECO Plus, and HT series of glass columns. Let’s explore the features of each series to help you choose the right glass column for your application.

YMC ECO Glass Columns: Versatile and reliable for MPLC

The YMC ECO glass columns are the go-to choice for medium-pressure liquid chromatography, capable of handling pressures from 5 to 30 bar, depending on the inner diameter. These columns are designed for versatility and accommodate a wide range of soft gels for different applications. ECO columns offer customisable options with one or two adjustable pistons and variants for both aqueous buffers (AB) and solvent-resistant (SR) applications. Precision-engineered with CNC technology, they feature a user-friendly screw-lock system for easy operation. Their robust design ensures reliable performance, making them compatible with any LC systems, including Äkta systems.

Figure 1: Overview of the features of the YMC ECO glass columns

YMC ECO Plus Glass Columns: Precision for high-pressure applications

For high-pressure applications, YMC ECO Plus glass columns are the ideal choice, capable of handling pressures up to 80 bar. These columns are suitable for both normal and reversed phase chromatography, as well as biochromatography, offering unparalleled adaptability. The quick-lock system simplifies assembly and maintenance, while Teflon chevrons (for SR versions) and O-rings (for AB versions) ensure secure sealing. Manufactured with high-precision CNC technology, the ECO Plus series delivers increased throughput and high reproducibility for every type of analysis.

Figure 2: Overview of the features of the YMC ECO Plus glass columns

YMC HT Glass Columns: Mastering high-temperature chromatography

For applications requiring elevated temperatures, the YMC HT Glass Columns are specifically designed to perform efficiently up to 70°C. These columns are perfect for biochromatography applications, where high temperatures are required. The integrated borosilicate glass jacket ensures optimal thermal management, leading to consistent chromatographic results across a broad range of separation modes, including normal phase, reversed phase, and ion-exchange chromatography. Compatible with a wide array of resins, the HT series is a top choice for scientists looking to achieve sophisticated and reliable high-temperature separations.

Figure 3: Overview of the features of YMC HT glass columns

Comparing YMC Glass Columns

YMC’s range of glass columns caters to every laboratory's needs. The ECO series is your best option for medium-pressure tasks, offering easy handling and compatibility with various soft gels. For high-pressure applications, the ECO Plus series provides increased throughput and faster runs, thanks to its higher-pressure limits and quick-lock system. Meanwhile, the HT series excels in high-temperature environments, ensuring precise control and efficient performance at elevated temperatures.

  YMC ECO YMC ECO Plus YMC HT
Available IDs 10, 15, 25, 50, 70, 80 mm 5, 10, 15, 25, 35, 50 mm 10, 15, 25, 50 mm
Available Bed Lengths 120, 200, 450, 750, 1000 mm 125, 250, 500 mm 120, 200, 300, 450, 750, 1000 mm
Column Volume Range 0 – 5 L 0 – 1 L 0 – 2 L
Pressure Limits (depends on ID) 30 – 5 bar AB: 80 – 30 bar
SR: 80 – 15 bar		 30 – 10 bar
Temperature Range 4 – 40° C 4 – 40° C 4 – 70° C
Advantages
  • Easy handling, equipped with screw-lock system
  • Compatible with any LC system
  • For use with all types of soft gels
  • 1 m long glass bodies for SEC applications
  • Easy assembly with Quick-Lock system
  • High pressure stability up to 80 bar
  • Increased throughput and faster runs
  • Columns with 5 mm ID for method development
  • Widest temperature range of 4 – 70 °C
  • Full resin compatibility
  • Borosilicate glass jacket for reliable column tempering
  • Frit technology allows optimal flow distribution
  • Useful for purification of oligonucleotides using AEX, RP or HIC

Table 1: Specifications of YMC laboratory scale glass columns. Options such as plunger length, aqueous buffer or solvent resistant versions, frit porosity, and a wide range of inner diameters are available for configuring glass columns to best suit the required application.

Conclusion

Choosing the right chromatography column is vital for achieving accurate and reliable results. YMC's ECO, ECO Plus, and HT glass columns offer customised solutions for a wide range of chromatographic applications, including medium-pressure, high-pressure, and high-temperature analyses. Explore YMC’s range today to elevate your chromatography experience and ensure your laboratory is equipped for success.