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GC-MS Training

1 Day

We have distilled critical knowledge of gas chromatography and mass spectrometry into a short, interactive course

Learn the absolute essentials of the technique and, using our unique multi-media examples and tutorial exercises, immediately enjoy the benefits when you return to the laboratory.

This course is designed to highlight the powerful possibilities of GC analysis with mass spectral detection. We explain tuning and tune reports and instruct you how to use them as a powerful diagnostic tool. 

We then discuss the functionality of the MS in detail including principles of quadrupole and ion trap mass filters. Ion detection devices will be explained, and the use of electron impact and chemical ionisation sources will be investigated with applicability to practical situations. GC parameters will also be considered with an explanation of the operation and troubleshooting of inlets and columns.

  

  • How the different components of the mass spectrometer work with the gas chromatograph, from the transfer line to the vacuum pumps
  • How ions are produced, filtered and detected, and the alternative ways different instruments achieve this
  • How tuning affects the instrument and the data generated, and how to benefit from this knowledge
  • The rich plethora of information that can be acquired and how to optimise instrument settings for high data quality

Chromatographic Considerations

  • Advantages of using MS vs other GC detectors
  • Column and ferrule selection
  • Gas purity

Ionisation

  • Electron Impact
  • Chemical Ionisation
  • The Ion source

MS Hardware

  • Why use a vacuum?
  • Controlling and monitoring vacuum
  • Quadrupole mass analysis explained
  • Matthieu stability diagrams
  • Other Analysers
  • Electron multipliers and detector electronics

Tuning and Calibration

  • Purpose of tuning
  • Tuning compounds
  • Explanation of auto-tune voltages
  • Troubleshooting from the auto-tune
  • User tuning and voltage ramping

Quantitation and Qualitative Analysis

  • Scan & SIM modes
  • High sensitivity data acquisition
  • Peak Purity
  • Library Matching
  • Internal Standards

Users of GC-MS equipment, or anyone interested in learning the analytical capabilities afforded by this type of instruments.

No previous knowledge of mass spectrometry is necessary, but an understanding of the fundamentals of gas chromatography is beneficial.

Interpretation of GC-MS Data

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