This training course provides a comprehensive overview of the entire dissolution testing process.
We cover all the basic theory behind dissolution, look at the use of type 1 and type 2 apparatus, including calibration, calculation and evaluation of results and method development considerations.
This not only provides a good introduction to those new to dissolution but also provides substantial information to labs looking to develop their own methods or improve existing practice—an invaluable insight into dissolution testing.
- Introduction – the human gastrointestinal tract and solid dose formulations
- Type 1 and Type 2 Dissolution apparatus
- Dissolution media
- System calibration and performance verification
- Calculation of results
- Method development
Basics of Dissolution Testing
- Overview of the human GI tract
- Conventional oral solid dose formulations
- Apparatus 1 and 2 methods
- Typical system setup
- Role of the media
- Common additives
- Manual and automated sampling
Calculation of Results
- Q and instant release
- Mass and volume correction
- Common causes of result failures
- Enhanced mechanical calibration
- Single and two-stage performance verification testing
- The development process
- Key method parameters
- Setting limits
This course is for analysts at many levels – for those new to dissolution testing who require a good foundation in the subject, more experienced analysts who need greater understanding to improve troubleshooting or labs needing to develop or optimise dissolution methods
Basic knowledge of chemistry is advantageous. Previous experience using dissolution equipment will be beneficial.
HPLC Method Development
Calibration and Quantitation