Agilent Bio MAb Columns

Agilent Bio MAb HPLC Columns

Thorough characterization of monoclonal antibodies includes the identification and monitoring of acidic and basic isoforms. The Agilent Bio MAb HPLC columns feature a unique resin specifically designed for high-resolution charge-based separations of monoclonal antibodies.

Bio MAb columns are available in 1.7 µm, 3 µm, 5 µm, and 10 µm sizes, providing higher resolution with the smaller particles. The Bio MAb column features a highly uniform, densely packed, weak cation exchange layer. This layer of the Bio MAb column is chemically bonded to the hydrophilic, polymeric coating of the Bio MAb column.

Agilent Bio MAb columns feature a unique resin specifically designed for high-resolution charge-based separations of monoclonal antibodies. Bio MAb columns are available in 1.7 μm, 3 μm, 5 μm, and 10 μm sizes, providing higher resolution with the smaller particles. The Bio MAb column features a highly uniform, densely packed, weak cation exchange layer. This layer of the Bio MAb column is chemically bonded to the hydrophilic, polymeric coating of the Bio MAb column.

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Part Number	Short Description	Phase	Particle Size	ID	Length	Pore Size	Type	Price
5190-2402	Agilent Bio MAb, NP1.7, 4 x 10mm, SS Guard	Agilent Bio MAb	1.7 um	4.0 mm	10 mm	Non-porous	SS Guard	£682.00
5190-2401	Agilent Bio MAb, NP1.7, 4.6 x 50mm, SS Column	Agilent Bio MAb	1.7 um	4.6 mm	50 mm	Non-porous	SS Column	£1,364.00
5190-2419	Agilent Bio MAb, NP10, 2.1 x 250mm, PK Column	Agilent Bio MAb	10 um	2.1 mm	250 mm	Non-porous	Peek Column	£1,720.00
5190-2420	Agilent Bio MAb, NP10, 2.1 x 50mm, PK Guard	Agilent Bio MAb	10 um	2.1 mm	50 mm	Non-porous	PEEK Guard	£746.00
5190-2414	Agilent Bio MAb, NP10, 4 x 10mm, SS Guard	Agilent Bio MAb	10 um	4.0 mm	10 mm	Non-porous	SS Guard	£487.00
5190-2415	Agilent Bio MAb, NP10, 4.6 x 250mm, PK Column	Agilent Bio MAb	10 um	4.6 mm	250 mm	Non-porous	Peek Column	£1,558.00
5190-2413	Agilent Bio MAb, NP10, 4.6 x 250mm, SS Column	Agilent Bio MAb	10 um	4.6 mm	250 mm	Non-porous	SS Column	£1,391.00
5190-2416	Agilent Bio MAb, NP10, 4.6 x 50mm, PK Guard	Agilent Bio MAb	10 um	4.6 mm	50 mm	Non-porous	PEEK Guard	£746.00
5190-2404	Agilent Bio MAb, NP3, 4 x 10mm, SS Guard	Agilent Bio MAb	3 um	4.0 mm	10 mm	Non-porous	SS Guard	£617.00
5190-2403	Agilent Bio MAb, NP3, 4.6 x 50mm, SS Column	Agilent Bio MAb	3 um	4.6 mm	50 mm	Non-porous	SS Column	£1,233.00
5190-6884	Agilent Bio MAb, NP5, 10 x 250mm, SS Column	Agilent Bio MAb	5 um	10.0 mm	250 mm	Non-porous	SS Column	£6,004.00
5190-2411	Agilent Bio MAb, NP5, 2.1 x 250mm, PK Column	Agilent Bio MAb	5 um	2.1 mm	250 mm	Non-porous	Peek Column	£1,980.00
5190-2412	Agilent Bio MAb, NP5, 2.1 x 50mm, PK Guard	Agilent Bio MAb	5 um	2.1 mm	50 mm	Non-porous	PEEK Guard	£973.00
5190-6885	Agilent Bio MAb, NP5, 21.2 x 250mm, SS Column	Agilent Bio MAb	5 um	21.2 mm	250 mm	Non-porous	SS Column	£19,499.00
5190-2406	Agilent Bio MAb, NP5, 4 x 10mm, SS Guard	Agilent Bio MAb	5 um	4.0 mm	10 mm	Non-porous	SS Guard	£551.00
5190-2407	Agilent Bio MAb, NP5, 4.6 x 250mm, PK Column	Agilent Bio MAb	5 um	4.6 mm	250 mm	Non-porous	Peek Column	£1,817.00
5190-2405	Agilent Bio MAb, NP5, 4.6 x 250mm, SS Column	Agilent Bio MAb	5 um	4.6 mm	250 mm	Non-porous	SS Column	£1,622.00
5190-2408	Agilent Bio MAb, NP5, 4.6 x 50mm, PK Guard	Agilent Bio MAb	5 um	4.6 mm	50 mm	Non-porous	PEEK Guard	£973.00

Features

A packing support composed of a rigid, spherical, highly cross-linked polystyrene divinylbenzene (PS/DVB) non-porous bead
Particles grafted with a hydrophilic, polymeric layer, virtually eliminating non-specific binding of antibody proteins
A different process is used to layer the weak cation-exchange phase to the particle making it a higher density than the Agilent Bio WCX column particles
Specifically designed for the separation of charge isoforms of monoclonal antibodies

Specifications

	Agilent Bio MAb
Phase	Weak cation exchange
Particle Type	Non-porous
Particle Size	1.7, 3, 5 and 10 µm
pH Range	2 - 12
Maximum Temperature	80°C
Hardware	Stainless Steel (1.7 µm, 3 µm, 5 µm, 10 µm) PEEK (5 µm, 10 µm)

Literature

Bio MAb PEEK Columns Flyer (684.49 kB)

Robust, reproducible retention and resolution with Agilent Bio MAb PEEK columns

Charge Variant Analysis Application Compendium (10.49 MB)

Collection of Agilent app notes on charge variant analysis

Charge Variant Analysis Workflow Ordering Guide (568.81 kB)

mAb charge variant analysis by weak cation exchange (WCX) chromatography

Agilent Bio HPLC Columns (26.00 MB)

Your essential resource for biomolecule analysis