Agilent Capsule Sinkers
Capsule wire, weights and sinker baskets are used to retain a solid dosage form at the bottom of the vessel for testing when the dosage form is buoyant. Depending on your dosage form a variety of options are available.
The flexible capsule wire meets USP requirements and has a 0.032 inch diameter. The stainless steel wire is twisted around the dosage form to provide sufficient mass and to ensure the dosage form sinks to the bottom of the vessel.
Sinker baskets are offered in a variety of mesh sizes and made of stainless steel. The press-on caps use O-rings to seal the basket once the dosage form is inserted. The Japanese Pharmacopoeia (JP) sinker basket is also available as an alternative.
A three-prong capsule weight can be used to retain your capsule for testing. These weights fit traditional capsule sizes one through three, and are sold individually.
Sinkers are used during a dissolution test to sink a dosage form that would otherwise float. The USP specifies that a small piece of non-reactive material, such as not more than a few turns of steel wire, can be attached to the dosage form to prevent floating. Other validated sinkers may also be used for this purpose.
Weights and sinker baskets may also be used for sticky dosage forms, as well as powders contained in capsule shells.
Sinker Basket Dimensions
|Inside diameter||20.3 mm / 0.8 inch|
|Outside diameter (with cover)||25 mm / 0.98 inch|
|Inside height||11.7 mm / 0.46 inch|
|Outside height (without cover)||15 mm / 0.59 inch|
|Outside height (with cover)||20 mm / 0.79 inch|
Excludes Japanese Pharmacopoeia sinker basket