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Acclaim Mixed-Mode

Acclaim Mixed-Mode HPLC Columns from Thermo Scientific

Acclaim Mixed-Mode HILIC-1

The Acclaim Mixed-Mode HILIC-1 column features a unique, high-efficiency, silica-based HPLC mixed-mode stationary phase that combines both reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC) properties. This combination allows both hydrophobic and hydrophilic interactions to be utilized to optimize separations.

The functional group is of a hydrophobic alkyl chain with a diol group at the terminus. This unique combination results in the adjustable selectivity, making Acclaim Mixed-Mode HILIC-1 separate mixtures that would be impossible for a C18 column. This column is suitable for a broad range of applications, including non-ionic ethoxylated surfactants, drug metabolites, lipids, polyethylene glycols (PEGs), ethoxylated surfactants, and more.

Acclaim Mixed-Mode WAX-1

The Acclaim Mixed-Mode WAX-1 is a novel, high-efficiency silica HPLC column that combines hydrophobic and weak anion exchange characteristics. Its unique chemistry results in a multimode separation mechanism that includes reversed-phase, anion exchange, and HILIC interactions. Selectivity can be adjusted by changing ionic strength, pH or organic solvent content.

Acclaim Mixed-Mode WCX-1

The Acclaim Mixed-Mode WCX-1 is a novel, high-efficiency, silica-based column, with a proprietary ligand with both hydrophobic and weak cation exchange properties. Selectivity of ionizable and neutral compounds can be controlled independently or simultaneously by tuning mobile phase ionic strength, pH or organic modifier. This column therefore can separate using multiple separation modes: reversed-phase, cation exchange, and normal-phase/HILIC and is recommended for a variety of industrial applications, including pharmaceutical, chemical, consumer products, foods and beverages.

Part Number Short Description Internal Diameter Particle Size Pore Size Phase Type Length Price Qty
064984 Acclaim Mixed-Mode WAX-1, 5um, 4.6 x 150mm 4.6 mm 5 um 120 A Mixed-Mode WAX Column 150 mm
£540.75
064985 Acclaim Mixed-Mode WAX-1, 5um, 4.6 x 250mm 4.6 mm 5 um 120 A Mixed-Mode WAX Column 250 mm
£633.15
066843 Acclaim Mixed-Mode HILIC-1, 5um, 4.6 x 150mm 4.6 mm 5 um 120 A Mixed-Mode HILIC Column 150 mm
£540.75
066844 Acclaim Mixed-Mode HILIC-1, 5um, 4.6 x 250mm 4.6 mm 5 um 120 A Mixed-Mode HILIC Column 250 mm
£633.15
066847 Acclaim Mixed-Mode HILIC-1, 5um, 2.1 x 150mm 2.1 mm 5 um 120 A Mixed-Mode HILIC Column 150 mm
£540.75
067084 Acclaim Mixed-Mode WAX-1, 5um, 2.1 x 150mm 2.1 mm 5 um 120 A Mixed-Mode WAX Column 150 mm
£540.75
068352 Acclaim Mixed-Mode WCX-1, 5um, 4.6 x 250mm 4.6 mm 5 um 120 A Mixed-Mode WCX Column 250 mm
£633.15
068353 Acclaim Mixed-Mode WCX-1, 5um, 4.6 x 150mm 4.6 mm 5 um 120 A Mixed-Mode WCX Column 150 mm
£544.95
068371 Acclaim Mixed-Mode WCX-1, 5um, 2.1 x 150mm 2.1 mm 5 um 120 A Mixed-Mode WCX Column 150 mm
£540.75
069686 Acclaim Mixed-Mode WAX-1, 5um, 2.1 x 10mm, Guard Cartridge, 2/pk 2.1 mm 5 um 120 A Mixed-Mode WAX Guard 10 mm
£145.95
069694 Acclaim Mixed-Mode HILIC-1, 5um, 2.1 x 10mm, Guard Cartridge, 2/pk 2.1 mm 5 um 120 A Mixed-Mode HILIC Guard 10 mm
£152.25
069704 Acclaim Mixed-Mode WAX-1, 5um, 4.6 x 10mm, Guard Cartridge, 2/pk 4.6 mm 5 um 120 A Mixed-Mode WAX Guard 10 mm
£145.95
069705 Acclaim Mixed-Mode WCX-1, 5um, 4.6 x 10mm, Guard Cartridge, 2/pk 4.6 mm 5 um 120 A Mixed-Mode WCX Guard 10 mm
£145.95
069706 Acclaim Mixed-Mode HILIC-1, 5um, 4.6 x 10mm, Guard Cartridge, 2/pk 4.6 mm 5 um 120 A Mixed-Mode HILIC Guard 10 mm
£145.95
070088 Acclaim Mixed-Mode WAX-1, 3um, 3 x 150mm 3.0 mm 3 um 120 A Mixed-Mode WAX Column 150 mm
£573.30
070089 Acclaim Mixed-Mode WAX-1, 3um, 2.1 x 150mm 2.1 mm 3 um 120 A Mixed-Mode WAX Column 150 mm
£573.30
070090 Acclaim Mixed-Mode HILIC-1, 3um, 3 x 150mm 3.0 mm 3 um 120 A Mixed-Mode HILIC Column 150 mm
£573.30
070091 Acclaim Mixed-Mode HILIC-1, 3um, 2.1 x 150mm 2.1 mm 3 um 120 A Mixed-Mode HILIC Column 150 mm
£573.30
070092 Acclaim Mixed-Mode WCX-1, 3um, 3 x 150mm 3.0 mm 3 um 120 A Mixed-Mode WCX Column 150 mm
£573.30
070093 Acclaim Mixed-Mode WCX-1, 3um, 2.1 x 150mm 2.1 mm 3 um 120 A Mixed-Mode WCX Column 150 mm
£573.30
071908 Acclaim Mixed-Mode WAX-1, 3um, 3 x 50mm 3.0 mm 3 um 120 A Mixed-Mode WAX Column 50 mm
£463.05
071909 Acclaim Mixed-Mode WAX-1, 5um, 3 x 10mm, Guard Cartridge, 2/pk 3.0 mm 5 um 120 A Mixed-Mode WAX Guard 10 mm
£145.95
071910 Acclaim Mixed-Mode WCX-1, 3um, 3 x 50mm 3.0 mm 3 um 120 A Mixed-Mode WCX Column 50 mm
£463.05
071911 Acclaim Mixed-Mode WCX-1, 5um, 3 x 10mm, Guard Cartridge, 2/pk 3.0 mm 5 um 120 A Mixed-Mode WCX Guard 10 mm
£145.95
071912 Acclaim Mixed-Mode HILIC-1, 3um, 3 x 50mm 3.0 mm 3 um 120 A Mixed-Mode HILIC Column 50 mm
£463.05
071913 Acclaim Mixed-Mode HILIC-1, 5um, 3 x 10mm, Guard Cartridge, 2/pk 3.0 mm 5 um 120 A Mixed-Mode HILIC Guard 10 mm
£145.95
088785 Acclaim Mixed-Mode WAX-1, 5um, 10 x 250mm 10.0 mm 5 um 120 A Mixed-Mode WAX Column 250 mm
£3,490.20

Acclaim Mixed-Mode HILIC-1

  • Uniquely designed for both reversed-phase and HILIC operations
  • Can operate in both RP and HILIC modes
  • Retains highly polar molecules
  • Unique selectivity complementary to RP columns
  • Broader application range compared with conventional diol-based columns
  • High-efficiency column for high-resolution separations

Acclaim Mixed-Mode WAX-1

  • Designed for separating anionic molecules with powerful adjustable selectivity control
  • Selectivity orthogonal to reversed-phase (RP) columns
  • Ideal selectivity for anionic molecules
  • Excellent column efficiency and peak asymmetry
  • Multimode retention mechanisms: reversed-phase, weak anion exchange, and HILIC modes

Acclaim Mixed-Mode WCX-1

  • Designed for separating cationic molecules with adjustable selectivity control
  • Ideal selectivity for separating basic molecules
  • Selectivity complementary to C18 RP columns
  • Multimode separation mechanism: reversed-phase, weak cation exchange, anion-exclusion and HILIC
  Acclaim Mixed-Mode HILIC-1 Acclaim Mixed-Mode WAX-1 Acclaim Mixed-Mode WCX-1
Phase Proprietary alkyl diol Proprietary alkyl Proprietary alkyl carboxylic group
Particle type Spherical, fully porous silica
Particle size 3, 5 µm
Pore size 120 Å
Surface area 300 m2/g
Endcapping Proprietary
pH range 2.5 - 7.5
Temperature range <50°C
USP code - L78 L85
Acclaim Mixed-Mode WCX-1 Product Specifications (503.17 kB)
For separating basic molecules
Acclaim Mixed-Mode Brochure (5.52 MB)
Columns for challenging separation needs
LC Columns Technical Guide (13.60 MB)
Selection charts based on stationary phase use, analyte properties, LC-MS requirements or USP specifications
Acclaim Column Selection Guide (96.31 kB)
Quick guide to choosing your Acclaim phase by application
Analytical UHPLC and HPLC Columns Brochure (11.02 MB)
Introduction to the broad range of chemistries and column families from Thermo Scientific
LC Columns Catalogue 2019-2021 (23.33 MB)
Innovative columns for fast LC, analytical HPLC and UHPLC
Acclaim Mixed-Mode HILIC-1 Product Specifications (330.66 kB)
A powerful tool for separating polar molecules
Acclaim-Mixed-Mode-WAX-1-Product-Specifications (474.21 kB)
Total control of selectivity
Acclaim Mixed-Mode HILIC-1 Product Manual (385.68 kB)
User guide for the Acclaim Mixed Mode HILIC-1 columns
Acclaim Mixed-Mode WAX-1 Product Manual (902.24 kB)
User guide for the Acclaim Mixed-Mode WAX-1 columns
Acclaim Mixed-Mode WCX-1 Product Manual (473.85 kB)
User guide for the Acclaim Mixed-Mode WCX-1 columns
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