AdvanceBio RP-mAb

AdvanceBio RP-mAb HPLC Columns from Agilent

Agilent AdvanceBio RP-mAb columns are designed to optimize the performance of intact and reduced mAb analysis when analyzing monoclonal antibodies for biopharma discovery, development, and QA/QC applications.

Analysis of intact and reduced monoclonal antibodies are critical measurements for characterizing therapeutic proteins and understanding their efficacy and stability. Poor chromatographic separations can result in rework and even compromise the accuracy of the characterization.

Based on Poroshell technology with unique engineering for pore size and bonded phases, AdvanceBio RP-mAb columns deliver higher resolution and faster run times to provide accurate, reproducible results. Available in a range of chemistries – SB-C8, C4, and diphenyl.

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Part Number	Short Description	Phase	Particle Size	ID	Length	Pore Size	Type	Price
795775-904	AdvanceBio RP-mAb C4 2.1 x 100mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	2.1 mm	100 mm	450 A	L26	£737.00
793775-904	AdvanceBio RP-mAb C4 2.1 x 150mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	2.1 mm	150 mm	450 A	L26	£803.00
799775-904	AdvanceBio RP-mAb C4 2.1 x 50mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	2.1 mm	50 mm	450 A	L26	£581.00
797775-904	AdvanceBio RP-mAb C4 2.1 x 75mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	2.1 mm	75 mm	450 A	L26	£660.00
795975-904	AdvanceBio RP-mAb C4 4.6 x 100mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	4.6 mm	100 mm	450 A	L26	£737.00
793975-904	AdvanceBio RP-mAb C4 4.6 x 150mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	4.6 mm	150 mm	450 A	L26	£803.00
799975-904	AdvanceBio RP-mAb C4 4.6 x 50mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	4.6 mm	50 mm	450 A	L26	£578.00
795775-944	AdvanceBio RP-mAb Diphenyl 2.1 x 100mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	2.1 mm	100 mm	450 A	L11	£737.00
793775-944	AdvanceBio RP-mAb Diphenyl 2.1 x 150mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	2.1 mm	150 mm	450 A	L11	£803.00
799775-944	AdvanceBio RP-mAb Diphenyl 2.1 x 50mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	2.1 mm	50 mm	450 A	L11	£581.00
797775-944	AdvanceBio RP-mAb Diphenyl 2.1 x 75mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	2.1 mm	75 mm	450 A	L11	£660.00
795975-944	AdvanceBio RP-mAb Diphenyl 4.6 x 100mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	4.6 mm	100 mm	450 A	L11	£737.00
793975-944	AdvanceBio RP-mAb Diphenyl 4.6 x 150mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	4.6 mm	150 mm	450 A	L11	£803.00
799975-944	AdvanceBio RP-mAb Diphenyl 4.6 x 50mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	4.6 mm	50 mm	450 A	L11	£578.00
785775-906	AdvanceBio RP-mAb SB-C8 2.1 x 100mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	2.1 mm	100 mm	450 A	L7	£737.00
783775-906	AdvanceBio RP-mAb SB-C8 2.1 x 150mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	2.1 mm	150 mm	450 A	L7	£803.00
789775-906	AdvanceBio RP-mAb SB-C8 2.1 x 50mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	2.1 mm	50 mm	450 A	L7	£581.00
787775-906	AdvanceBio RP-mAb SB-C8 2.1 x 75mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	2.1 mm	75 mm	450 A	L7	£660.00
785975-906	AdvanceBio RP-mAb SB-C8 4.6 x 100mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	4.6 mm	100 mm	450 A	L7	£737.00
783975-906	AdvanceBio RP-mAb SB-C8 4.6 x 150mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	4.6 mm	150 mm	450 A	L7	£803.00
789975-906	AdvanceBio RP-mAb SB-C8 4.6 x 50mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	4.6 mm	50 mm	450 A	L7	£578.00

Features

Improved accuracy - superficially porous particles (3.5 µm) with wide pores (450 Å) increase mAb resolution while maintaining compatibility with all LC instruments
Speed - shorter analysis times compared to columns packed with fully porous particles of the same size
Lower costs - the robust Poroshell packed bed and 2 µ inlet frit extend column lifetime by helping prevent inlet blockage
Flexible method development: range of chemistries - SB-C8, C4, and diphenyl

Specifications

	Pore Size	Temp Limits*	pH range*	Endcapped
AdvanceBio RP-mAb C4	450 Å	90 °C	1 - 8	Yes
AdvanceBio RP-mAb SB-C8	450 Å	90 °C	1 - 8	No
AdvanceBio RP-mAb Diphenyl	450 Å	90 °C	1 - 8	Yes

*Columns are designed for optimal use at low pH. At pH 6 - 8, highest column stability for all silica-based columns is obtained by operating at temperatures <40 °C and using low buffer concentrations in the range of 0.01-0.02 M.

Literature

Agilent Bio HPLC Columns (26.00 MB)

Your essential resource for biomolecule analysis

Agilent AdvanceBio RP-mAb columns brochure (1.18 MB)

Resolve mAbs faster and better with Agilent AdvanceBio RP-mAb columns