Regis ChiroSil Crown Ether Chiral Columns

ChiroSil Crown Ether Chiral Columns from Regis

ChiroSil columns are ideal for the separation of chiral compounds containing primary amines and natural and unnatural amino acids and their derivatives. Chirosil/ME RCA (+) and SCA (-) have (+) or (-)-(18-Crown-6)-tetracarboxylic acid as a chiral selector, which is covalently bonded to the silica support, ensuring excellent column durability. The ChiroSil CSP is compatible with both normal phase and reversed-phase HPLC and is available in both analytical and preparative dimensions. It is also available in both enantiomeric forms (RCA (+) or SCA (-)), which allows for inversion of peak elution order, which can be beneficial for preparative separations.

In the case of amino acids, most L-enantiomers elute first on the ChiroSil RCA(+) and D-enantiomers elute first on the ChiroSil SCA(-) column.

In general, the separation factors and resolution factors for analytes on ChiroSil are greater than on ChiroSil ME, while capacity factors on ChiroSil ME are greater than on ChiroSil.

Regis ChiroSil Crown Ether chiral columns are ideal for the separation of chiral compounds containing primary amines and natural and unnatural amino acids and their derivatives. Chirosil/ME RCA (+) and SCA (-) have (+) or (-)-(18-Crown-6)-tetracarboxylic acid as a chiral selector, which is covalently bonded to the silica support, ensuring excellent column durability.

The ChiroSil CSP is compatible with both normal phase and reversed-phase HPLC and is available in both analytical and preparative dimensions. It is also available in both enantiomeric forms (RCA (+) or SCA (-)), which allows for inversion of peak elution order, which can be beneficial for preparative separations.

In the case of amino acids, most L-enantiomers elute first on the ChiroSil RCA(+) and D-enantiomers elute first on the ChiroSil SCA(-) column. In general, the separation factors and resolution factors for analytes on ChiroSil are greater than on ChiroSil ME, while capacity factors on ChiroSil ME are greater than on ChiroSil.

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Part Number	Short Description	Phase Type	Phase	USP	Particle Size	ID	Length	Pore Size	Type	Price
1-788005-300	ChiroSil ME RCA(+) Analytical Column 10um 150 x 4.6mm		ChiroSil ME RCA (+)		10 um	4.6 mm	150 mm	100 A	Analytical Column	£1,979.31
1-788006-300	ChiroSil ME RCA(+) Analytical Column 10um 250 x 4.6mm		ChiroSil ME RCA (+)		10 um	4.6 mm	250 mm	100 A	Analytical Column	£2,083.86
1-788001-300	ChiroSil ME RCA(+) Analytical Column 5um 150 x 4.6mm		ChiroSil ME RCA (+)		5 um	4.6 mm	150 mm	100 A	Analytical Column	£1,979.31
1-788002-300	ChiroSil ME RCA(+) Analytical Column 5um 250 x 4.6mm		ChiroSil ME RCA (+)		5 um	4.6 mm	250 mm	100 A	Analytical Column	£2,083.86
1-788013-300	ChiroSil ME SCA(-) Analytical Column 10um 150 x 4.6mm		ChiroSil ME SCA (-)		10 um	4.6 mm	150 mm	100 A	Analytical Column	£1,979.31
1-788014-300	ChiroSil ME SCA(-) Analytical Column 10um 250 x 4.6mm		ChiroSil ME SCA (-)		10 um	4.6 mm	250 mm	100 A	Analytical Column	£2,083.86
1-788009-300	ChiroSil ME SCA(-) Analytical Column 5um 150 x 4.6mm		ChiroSil ME SCA (-)		5 um	4.6 mm	150 mm	100 A	Analytical Column	£1,979.31
1-788010-300	ChiroSil ME SCA(-) Analytical Column 5um 250 x 4.6mm		ChiroSil ME SCA (-)		5 um	4.6 mm	250 mm	100 A	Analytical Column	£2,083.86
1-799014-300	ChiroSil RCA(+) Analytical Column 10um 250 x 4.6mm		ChiroSil RCA (+)	L117	10 um	4.6 mm	250 mm	100 A	Analytical Column	£1,960.46
1-799010-300	ChiroSil RCA(+) Analytical Column 5um 100 x 3mm		ChiroSil RCA (+)	L117	5 um	3.0 mm	100 mm	100 A	Analytical Column	£1,682.04
1-799008-300	ChiroSil RCA(+) Analytical Column 5um 100 x 4.6mm		ChiroSil RCA (+)	L117	5 um	4.6 mm	100 mm	100 A	Analytical Column	£1,734.31
1-799001-300	ChiroSil RCA(+) Analytical Column 5um 150 x 4.6mm		ChiroSil RCA (+)	L117	5 um	4.6 mm	150 mm	100 A	Analytical Column	£1,781.38
1-799002-300	ChiroSil RCA(+) Analytical Column 5um 250 x 4.6mm		ChiroSil RCA (+)	L117	5 um	4.6 mm	250 mm	100 A	Analytical Column	£1,960.46
1-799200-300	ChiroSil RCA(+) Guard Column 5um 10 x 3mm 3/pk		ChiroSil RCA (+)	L117	5 um	3.0 mm	10 mm	100 A	Guard	£222.84
1-799114-300	ChiroSil SCA(-) Analytical Column 10um 250 x 4.6mm	L66	ChiroSil SCA (-)		10 um	4.6 mm	250 mm	100 A	Analytical Column	£1,960.46
1-799107-300	ChiroSil SCA(-) Analytical Column 5um 100 x 3mm	L66	ChiroSil SCA (-)		5 um	3.0 mm	100 mm	100 A	Analytical Column	£1,682.04
1-799108-300	ChiroSil SCA(-) Analytical Column 5um 100 x 4.6mm	L66	ChiroSil SCA (-)		5 um	4.6 mm	100 mm	100 A	Analytical Column	£1,734.31
1-799101-300	ChiroSil SCA(-) Analytical Column 5um 150 x 4.6mm	L66	ChiroSil SCA (-)		5 um	4.6 mm	150 mm	100 A	Analytical Column	£1,781.38
1-799102-300	ChiroSil SCA(-) Analytical Column 5um 250 x 4.6mm	L66	ChiroSil SCA (-)		5 um	4.6 mm	250 mm	100 A	Analytical Column	£1,960.46
1-799100-300	ChiroSil SCA(-) Guard Column 5um 10 x 3mm 3/pk	L66	ChiroSil SCA (-)		5 um	3.0 mm	10 mm	100 A	Guard	£222.84

Features

ChiroSil RCA(+) and SCA(-) are proven chiral stationary phases for the separation of amino acids and compounds containing primary amines
Chirosil ME is for applications where greater retention and capacity are needed
Excellent durability due to covalent bonding
Available in both enantiomeric forms [RCA(+) and SCA(-)], which allows for the inversion of peak elution order
Columns are stable to 5,000 psi (~345 bar)
Columns are available in 5 and 10 µm particle sizes and analytical and preparative dimensions

Specifications

Column	Selector/Phase Type
ChiroSil RCA(+)	(+)-(18-Crown-6)-tetracarboxylic acid
ChiroSil SCA(-)	(-)-(18-Crown-6)-tetracarboxylic acid
ChiroSil ME RCA(+)	(+)-(18-Crown-6)-tetracarboxylic acid
ChiroSil ME SCA(-)	(-)-(18-Crown-6)-tetracarboxylic acid

Literature