YMC BioPro SmartSep Columns

BioPro IEX Media and Preparative Columns from YMC

Ion exchange chromatography (IEX) is widely used in the analysis and purification of bio-molecules. Using reversible charge-charge interactions offers several advantages in comparison to other chromatographic methods, e.g. high capacity and fast throughput. For these reasons, IEX is often used in the capture or intermediate purification of bio-molecules.

BioPro is a series of ion exchange resins specifically designed for use in bio-chromatography. The media is based on a hydrophilic polymer matrix, with particle sizes of 10, 20, 30, or 75 µm. It is available as a strong anion exchanger (BioPro QA) or a strong cation exchanger (BioPro SP). BioPro offers a high dynamic binding capacity (DBC), together with low non-specific adsorption and excellent recovery.

The BioPro Ion Exchange Screening Kits consist of columns that are packed with resins designed for the separation of proteins, nucleotides, and other biomolecules. The available phases are strong anion exchanger (BioPro SmartSep Q), strong cation exchanger (BioPro SmartSep S), weak anion exchanger (BioPro DA) and weak cation exchanger (BioPro CM).

BioPro IEX and BioPro IEX SmartSep from YMC form a series of ion exchange resins specifically designed for biochromatography. It is available as a strong anion exchanger (BioPro IEX Q) and a strong cation exchanger (BioPro IEX S). The media is based on a hydrophilic polymer matrix, with a particle size of 10 µm, 20 µm, 30 µm, and 75 µm. BioPro IEX resins with a 75 µm particle size are especially suited for the initial capture step while the BioPro IEX SmartSep 10 µm, 20 µm, and 30 µm, are the ideal choices for the intermediate purification and polishing processes. BioPro IEX is manufactured in lot sizes up to 450 L.

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Part Number	Short Description	Phase	Particle Size	ID	Length	Pore Size	Type	Price
QSA0S10-1010WT	BioPro IEX SmartSep Q10 Column, 10um, 100 x 10mm	BioPro IEX SmartSep Q10	10 um	10.0 mm	100 mm		Column	£4,176.41
QSA0S10-1020WT	BioPro IEX SmartSep Q10 Column, 10um, 100 x 20mm	BioPro IEX SmartSep Q10	10 um	20.0 mm	100 mm		Column	£9,097.25
QSA0S10-1046WP	BioPro IEX SmartSep Q10 Column, 10um, 100 x 4.6mm	BioPro IEX SmartSep Q10	10 um	4.6 mm	100 mm		Column	£1,664.11
QSA0S10-1510WT	BioPro IEX SmartSep Q10 Column, 10um, 150 x 10mm	BioPro IEX SmartSep Q10	10 um	10.0 mm	150 mm		Column	£4,404.60
QSA0S10-1520WT	BioPro IEX SmartSep Q10 Column, 10um, 150 x 20mm	BioPro IEX SmartSep Q10	10 um	20.0 mm	150 mm		Column	£9,491.49
QSA0S10-1546WT	BioPro IEX SmartSep Q10 Column, 10um, 150 x 4.6mm	BioPro IEX SmartSep Q10	10 um	4.6 mm	150 mm		Column	£2,175.74
QSA0S10-2510WT	BioPro IEX SmartSep Q10 Column, 10um, 250 x 10mm	BioPro IEX SmartSep Q10	10 um	10.0 mm	250 mm		Column	£5,180.19
QSA0S10-2520WT	BioPro IEX SmartSep Q10 Column, 10um, 250 x 20mm	BioPro IEX SmartSep Q10	10 um	20.0 mm	250 mm		Column	£6,178.26
QSA0S10-2546WT	BioPro IEX SmartSep Q10 Column, 10um, 250 x 4.6mm	BioPro IEX SmartSep Q10	10 um	4.6 mm	250 mm		Column	£2,657.12
QSA0S20-1010WT	BioPro IEX SmartSep Q20 Column, 20um, 100 x 10mm	BioPro IEX SmartSep Q20	20 um	10.0 mm	100 mm		Column	£4,176.41
QSA0S20-1510WT	BioPro IEX SmartSep Q20 Column, 20um, 150 x 10mm	BioPro IEX SmartSep Q20	20 um	10.0 mm	150 mm		Column	£4,404.60
QSA0S20-2510WT	BioPro IEX SmartSep Q20 Column, 20um, 250 x 10mm	BioPro IEX SmartSep Q20	20 um	10.0 mm	250 mm		Column	£5,180.19
BPQSA0S20-01PK	BioPro IEX SmartSep Q20, 100nm, 20um, 1mL column (5 per unit)	BioPro IEX SmartSep Q20	20 um			1000 A	Column	£237.88
BPQSA0S20-05PK	BioPro IEX SmartSep Q20, 100nm, 20um, 5mL column (5 per unit)	BioPro IEX SmartSep Q20	20 um			1000 A	Column	£571.67
QSA0S30-1010WT	BioPro IEX SmartSep Q30 Column, 30um, 100 x 10mm	BioPro IEX SmartSep Q30	30 um	10.0 mm	100 mm		Column	£4,176.41
QSA0S30-1046WP	BioPro IEX SmartSep Q30 Column, 30um, 100 x 4.6mm	BioPro IEX SmartSep Q30	30 um	4.6 mm	100 mm		Column	£1,664.11
QSA0S30-1510WT	BioPro IEX SmartSep Q30 Column, 30um, 150 x 10mm	BioPro IEX SmartSep Q30	30 um	10.0 mm	150 mm		Column	£4,404.60
QSA0S30-1520WT	BioPro IEX SmartSep Q30 Column, 30um, 150 x 20mm	BioPro IEX SmartSep Q30	30 um	20.0 mm	150 mm		Column	£9,491.49
QSA0S30-2510WT	BioPro IEX SmartSep Q30 Column, 30um, 250 x 10mm	BioPro IEX SmartSep Q30	30 um	10.0 mm	250 mm		Column	£5,180.19
BPQSA0S30-01PK	BioPro IEX SmartSep Q30, 100nm, 30um, 1mL column (5 per unit)	BioPro IEX SmartSep Q30	30 um			1000 A	Column	£237.88
BPQSA0S30-05PK	BioPro IEX SmartSep Q30, 100nm, 30um, 5mL column (5 per unit)	BioPro IEX SmartSep Q30	30 um			1000 A	Column	£571.67
SSA0S10-1010WT	BioPro IEX SmartSep S10 Column, 10um, 100 x 10mm	BioPro IEX SmartSep S10	10 um	10.0 mm	100 mm		Column	£5,392.23
SSA0S10-1020WT	BioPro IEX SmartSep S10 Column, 10um, 100 x 20mm	BioPro IEX SmartSep S10	10 um	20.0 mm	100 mm		Column	£7,334.04
SSA0S10-1030WT	BioPro IEX SmartSep S10 Column, 10um, 100 x 30mm	BioPro IEX SmartSep S10	10 um	30.0 mm	100 mm		Column	£11,178.23
SSA0S10-1546WT	BioPro IEX SmartSep S10 Column, 10um, 150 x 4.6mm	BioPro IEX SmartSep S10	10 um	4.6 mm	150 mm		Column	£2,175.74
SSA0S10-2510WT	BioPro IEX SmartSep S10 Column, 10um, 250 x 10mm	BioPro IEX SmartSep S10	10 um	10.0 mm	250 mm		Column	£4,594.80
SSA0S10-2520WT	BioPro IEX SmartSep S10 Column, 10um, 250 x 20mm	BioPro IEX SmartSep S10	10 um	20.0 mm	250 mm		Column	£6,178.26
SSA0S10-2530WT	BioPro IEX SmartSep S10 Column, 10um, 250 x 30mm	BioPro IEX SmartSep S10	10 um	30.0 mm	250 mm		Column	£9,838.01
SSA0S10-2546WT	BioPro IEX SmartSep S10 Column, 10um, 250 x 4.6mm	BioPro IEX SmartSep S10	10 um	4.6 mm	250 mm		Column	£2,657.12
SSA0S20-1510WT	BioPro IEX SmartSep S10 Column, 20um, 150 x 10mm	BioPro IEX SmartSep S10	20 um	10.0 mm	150 mm		Column	£4,404.60
SSA0S10-0520WTG	BioPro IEX SmartSep S10 Guard Column, 10um, 50 x 20mm	BioPro IEX SmartSep S10	10 um	20.0 mm	50 mm		Guard	£2,689.85
SSA0S10-1046WP	BioPro IEX SmartSep S10, PEEK Column, 100nm, 10um, 100 x 4.6mm	BioPro IEX SmartSep S10	10 um	4.6 mm	100 mm		PEEK Column	£1,649.36
BPSSA0S20-01PK	BioPro IEX SmartSep S20, 100nm, 20um, 1mL column (5 per unit)	BioPro IEX SmartSep S20	20 um			1000 A	Column	£237.88
BPSSA0S20-05PK	BioPro IEX SmartSep S20, 100nm, 20um, 5mL column (5 per unit)	BioPro IEX SmartSep S20	20 um			1000 A	Column	£571.67
SSA0S30-1046WP	BioPro IEX SmartSep S30 Column, 30um, 100 x 4.6mm	BioPro IEX SmartSep S30	30 um	4.6 mm	100 mm		Column	£1,664.11
BPSSA0S30-01PK	BioPro IEX SmartSep S30, 100nm, 30um, 1mL column (5 per unit)	BioPro IEX SmartSep S30	30 um			1000 A	Column	£237.88
BPSSA0S30-05PK	BioPro IEX SmartSep S30, 100nm, 30um, 5mL column (5 per unit)	BioPro IEX SmartSep S30	30 um			1000 A	Column	£571.67
BPQAA0S75-01PK	BioPro Q75, 100nm, 75um, 1mL column (5 per unit)	BioPro Q75	75 um			1000 A	Column	£237.88
BPQAA0S75-05PK	BioPro Q75, 100nm, 75um, 5mL column (5 per unit)	BioPro Q75	75 um			1000 A	Column	£571.67
BPSPA0S75-01PK	BioPro S75, 100nm, 75um, 1mL column (5 per unit)	BioPro S75	75 um			1000 A	Column	£237.88
BPSPA0S75-05PK	BioPro S75, 100nm, 75um, 5mL column (5 per unit)	BioPro S75	75 um			1000 A	Column	£571.67
BPSIA0S99-05PK	Ion Exchange Selection Kit (BioPro IEX Q75/Q30/S75/S30), 4 x 5 mL columns	Multiple					Kit	£623.21
BPSIA0S99-01PK	Ion Exchange Selection Kit (BioPro IEX Q75/S75/Q30/S30), 4 x 1 mL columns	Multiple					Kit	£265.55
QSA0S10-2046WT	BioPro IEX SmartSep Q10 Column, 10um, 200 x 4.6mm	BioPro IEX SmartSep Q10	10 um	4.6 mm	200 mm		Column	£2,657.12
QSA0S20-2046WT	BioPro IEX SmartSep Q20 Column, 20um, 200 x 4.6mm	BioPro IEX SmartSep Q20	20 um	4.6 mm	200 mm		Column	£2,657.12
QSA0S20-1520WT	BioPro IEX SmartSep Q20 Column, 20um, 150 x 20mm	BioPro IEX SmartSep Q20	20 um	20.0 mm	150 mm		Column	£9,491.49
QSA0S20-2520WT	BioPro IEX SmartSep Q20 Column, 20um, 250 x 20mm	BioPro IEX SmartSep Q20	20 um	20.0 mm	250 mm		Column	£6,178.26
QSA0S30-2520WT	BioPro IEX SmartSep Q30 Column, 30um, 250 x 20mm	BioPro IEX SmartSep Q30	30 um	20.0 mm	250 mm		Column	£6,178.26

Features

Excellent dynamic binding capacity
High capacity even at high flow rates
Increased productivity
Low non-specific adsorption and high recovery
Full compliances with GMP requirements
Reduced processing costs

Specifications

Anion Exchange Resins

	BioPro IEX SmartSep Q10	BioPro IEX SmartSep Q20	BioPro IEX SmartSep Q30	BioPro IEX Q75
Ion Exchange Type	strong anion exchanger	strong anion exchanger	strong anion exchanger	strong anion exchanger
Charged Group	-R-N⁺(CH₃)₃	-R-N⁺(CH₃)₃	-R-N⁺(CH₃)₃	-R-N⁺(CH₃)₃
Base Material	hydrophilic polymer beads	hydrophilic polymer beads	hydrophilic polymer beads	hydrophilic polymer beads
Particle Size	10 µm	20 µm	30 µm	75 µm
pH Range	2 - 12	2 - 12	2 - 12	2 - 12
Ion Exchange Capacity	min. 0.08 meq/mL resin	min. 0.08 meq/mL resin	min. 0.08 meq/mL resin	min. 0.10 meq/mL resin
Dynamic Binding Capacity	min. 110 (BSA)	min. 110 (BSA)	min. 110 (BSA)	min. 160 (BSA)
Compression Factor	1.05 - 1.15	1.05 - 1.15	1.05 - 1.15	1.05 - 1.15
Typical Flow Rate	200-1000 cm/h, max. 2000 cm/h	200-1000 cm/h, max. 2000 cm/h	200-1000 cm/h, max. 2000 cm/h	200-1000 cm/h, max. 2000 cm/h
Pressure Limit	40 bar	30 bar	30 bar	3 bar

Cation Exchange Resins

	BioPro IEX SmartSep S10	BioPro IEX SmartSep S20	BioPro IEX SmartSep S30	BioPro IEX S75
Ion Exchange Type	strong cation exchanger	strong cation exchanger	strong cation exchanger	strong cation exchanger
Charged Group	-R-SO₃-	-R-SO₃-	-R-SO₃-	-R-SO₃-
Base Material	hydrophilic polymer beads	hydrophilic polymer beads	hydrophilic polymer beads	hydrophilic polymer beads
Particle Size	10 µm	20 µm	30 µm	75 µm
pH Range	2 - 12	2 - 12	2 - 12	2 - 12
Ion Exchange Capacity	min. 0.08 meq/mL resin	min. 0.08 meq/mL resin	min. 0.08 meq/mL resin	min. 0.10 meq/mL resin
Dynamic Binding Capacity	min. 110 (Lysozyme)	min. 110 (Lysozyme)	min. 110 (Lysozyme)	min. 160 (Lysozyme)
Compression Factor	1.05 - 1.15	1.05 - 1.15	1.05 - 1.15	1.05 - 1.15
Typical Flow Rate	200-1000 cm/h, max. 2000 cm/h	200-1000 cm/h, max. 2000 cm/h	200-1000 cm/h, max. 2000 cm/h	200-1000 cm/h, max. 2000 cm/h
Pressure Limit	40 bar	30 bar	30 bar	3 bar