Regis Supercritical Fluid Chromatography (SFC) Columns

More chemists are discovering the benefits of supercritical fluid chromatography (SFC) as a greener alternative to HPLC separation of complex samples containing a range of different functional groups and polarities. The use of compressed carbon dioxide (CO₂) as the primary mobile phase provides many benefits: it is readily available, relatively inexpensive, and safe. It can also be recycled, leading to SFC’s designation as a “green” technology. Additionally, the viscosities of compressed CO₂ and mixtures with polar modifiers are much lower than those of aqueous mixtures. This allows chromatographic run times to be approximately one third to one-fifth as long as typical HPLC runs. Ultimately, SFC provides faster separation and higher sample throughput compared to HPLC.