Thermo Scientific MAbPac HIC Columns

The Thermo Scientific MAbPac HIC column family is designed for separation of monoclonal antibodies and related biologics by hydrophobic interaction chromatography (HIC). These columns are designed to address the separation challenges as the result of heterogeneity, complexity, and diversity of mAbs and related biologics.

The MAbPac HIC-10 is the column of choice for intact mAbs/proteins and mAb aggregates while the MAbPac HIC-20 is suited to resolve mAb fragments, oxidized mAbs and bispecific mAbs. When it comes to ADCs, MAbPac HIC-Butyl is ideal for cystein-conjugated ADC while MAbPac HIC-10 and MAbPac HIC-20 have proven useful for several cysteine proprietary ADC molecules.

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Part Number	Short Description	Phase	Particle Size	ID	Length	Pore Size	Type	Price
088480	MAbPac HIC-10, 5um, 4.6 x 100mm, Column	MAbPac HIC-10	5 um	4.6 mm	100 mm	1000 A	Column	£978.55
088481	MAbPac HIC-10, 5um, 4.6 x 250mm, Column	MAbPac HIC-10	5 um	4.6 mm	250 mm	1000 A	Column	£1,419.43
088482	MAbPac HIC-10, 5um, 4.6 x 10mm, Guard Cartridge, 2pk	MAbPac HIC-10	5 um	4.6 mm	10 mm	1000 A	Guard	£160.96
088553	MAbPac HIC-20, 5um, 4.6 x 100mm, Column	MAbPac HIC-20	5 um	4.6 mm	100 mm	1000 A	Column	£978.55
088554	MAbPac HIC-20, 5um, 4.6 x 250mm, Column	MAbPac HIC-20	5 um	4.6 mm	250 mm	1000 A	Column	£1,419.43
088555	MAbPac HIC-20, 5um, 4.6 x 10mm, Guard Cartridge, 2pk	MAbPac HIC-20	5 um	4.6 mm	10 mm	1000 A	Guard	£162.04
088558	MAbPac HIC-Butyl, 5um, 4.6 x 100mm, Column	MAbPac HIC-Butyl	5 um	4.6 mm	100 mm	Non-porous	Column	£978.55
088559	MAbPac HIC-Butyl, 5um, 4.6 x 10mm, Guard Cartridge, 2pk	MAbPac HIC-Butyl	5 um	4.6 mm	10 mm	Non-porous	Guard	£160.96
SP6961	MAbPac HIC-20, 5um, 10 x 150mm, Column	MAbPac HIC-20	5 um	10 mm	150 mm	1000 A	Column	£4,405.25
SP6995	MAbPac HIC-20, 5um, 10 x 250mm, Column	MAbPac HIC-20	5 um	10 mm	250 mm	1000 A	Column	£6,555.96
SP6965	MAbPac HIC-Butyl, 5um, 7.8 x 100mm, Column	MAbPac HIC-Butyl	5 um	7.8 mm	100 mm	Non-porous	Column	£1,866.14
SP6997	MAbPac HIC-10, 5um, 7.8 x 100mm, Column	MAbPac HIC-10	5 um	7.8 mm	100 mm	1000 A	Column	£1,841.65

Features

Advanced column chemistry designed for separating mAbs and related biologics
Broad selectivity coverage for most challenging separations of mAbs
Excellent bio-compatibility
High column efficiency
Rugged column packing

Specifications

	MAbPac HIC-10	MAbPac HIC-20	MAbPac HIC-Butyl
Phase	Proprietary polyamide	Proprietary amide	Butyl
Particle Type	Spherical, high purity silica	Spherical, high purity silica	Hydrophilic polymer
Particle Size	5 µm	5 µm	5 µm
Pore Size	1000 Å	1000 Å	Non-porous
pH Range	2 - 8	2 - 9	2 - 12
Maximum Temperature	60°C	60°C	60°C
Aqueous Compatibility	0 - 100%	0 - 100%	0 - 100%
Organic Compatibility	0 - 100%	0 - 100%	0 - 50%

Literature