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YMC BioPro HIC Columns

YMC-Triart BioPro HIC BF Analytical HPLC Columns

The YMC BioPro HIC BF is a hydrophobic interaction chromatography (HIC) column utilizing a butyl (C4) stationary phase bonded to non-porous hydrophilic polymer particles. This HIC phase is specifically designed for fast, high resolution separations of proteins and biopharmaceutical drugs such as monoclonal antibodies (mAb’s), including drug-to-antibody ratio (DAR) analysis of antibody drug conjugates (ADC’s).

YMC BioPro HIC columns are designed and optimised for analysis and lab-scale purification of antibodies, antibody-drug conjugates, and other proteins. BioPro HIC HT and BioPro HIC BF columns are based on a non-porous hydrophobic polymer. Optimised surface modification and column packing method realise high separation performance. High-throughput analysis with a faster flow rate can be achieved together with a high resolution using BioPro HIC HT. The rigid particle provides higher pressure tolerance compared to other HIC columns, which allows higher flow rates and therefore shorter analysis times.

Part Number Short Description Phase Particle Size ID Length Pore Size Type Price Qty
BHB00S04-1046WT BioPro HIC BF, non-porous, 4um, 100 x 4.6mm BioPro HIC BF 4 um 4.6 mm 100 mm Non-porous Column
BHH00SQ3-1046PTH BioPro HIC HT, non-porous, 2.3um, 100 x 4.6mm BioPro HIC HT 2.3 um 4.6 mm 100 mm Non-porous Column
BHB00S04-1010WT BioPro HIC BF, non-porous, 4um, 100 x 10mm BioPro HIC BF 4 um 10.0 mm 100 mm Non-porous Column
BHH00SQ3-H346PTH BioPro HIC HT, non-porous, 2.3um, 33 x 4.6mm, PTH Hardware BioPro HIC HT 2.3 um 4.6 mm 33 mm Non-porous Column
  • Specifically designed for drug-to-antibody conjugates (ADCs) and antibodies
  • Ideal drug-to-antibody ratio (DAR) analysis
  • High throughput by reducing analysis time
  • Excellent batch-to-batch reproducibility
  • Long term stability
  BioPro HIC HT BioPro HIC BF
Base Particle Hydrophilic polymer (polymethacrylate) Hydrophilic polymer (polymethacrylate)
Functional Group Butyl Butyl
Particle Size 2.3 µm 4 µm
Pore Size Non-porous Non-porous
Temperature Range 10 – 60°C 10 – 60°C
pH Range 2 – 12 2 – 12
Pressure Limit 400 bar 200 bar
YMC Biochromatography Columns Catalogue (11.43 MB)
Overview of YMC's range of columns for biochromatography
YMC Phase Overview BioLC (2.12 MB)
Stationary phases for Bio LC from YMC
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