YMC BioPro HIC Columns

YMC-Triart BioPro HIC BF Analytical HPLC Columns

The YMC BioPro HIC BF is a hydrophobic interaction chromatography (HIC) column utilizing a butyl (C4) stationary phase bonded to non-porous hydrophilic polymer particles. This HIC phase is specifically designed for fast, high resolution separations of proteins and biopharmaceutical drugs such as monoclonal antibodies (mAb’s), including drug-to-antibody ratio (DAR) analysis of antibody drug conjugates (ADC’s).

YMC BioPro HIC columns are designed and optimised for analysis and lab-scale purification of antibodies, antibody-drug conjugates, and other proteins. BioPro HIC HT and BioPro HIC BF columns are based on a non-porous hydrophobic polymer. Optimised surface modification and column packing method realise high separation performance. High-throughput analysis with a faster flow rate can be achieved together with a high resolution using BioPro HIC HT. The rigid particle provides higher pressure tolerance compared to other HIC columns, which allows higher flow rates and therefore shorter analysis times.

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Buy

Part Number	Short Description	Phase	Particle Size	ID	Length	Pore Size	Type	Price
BHB00S04-1046WT	BioPro HIC BF, non-porous, 4um, 100 x 4.6mm	BioPro HIC BF	4 um	4.6 mm	100 mm	Non-porous	Column	£1,606.96
BHH00SQ3-1046PTH	BioPro HIC HT, non-porous, 2.3um, 100 x 4.6mm	BioPro HIC HT	2.3 um	4.6 mm	100 mm	Non-porous	Column	£1,780.23
BHB00S04-1010WT	BioPro HIC BF, non-porous, 4um, 100 x 10mm	BioPro HIC BF	4 um	10.0 mm	100 mm	Non-porous	Column	£11,152.76
BHH00SQ3-H346PTH	BioPro HIC HT, non-porous, 2.3um, 33 x 4.6mm, PTH Hardware	BioPro HIC HT	2.3 um	4.6 mm	33 mm	Non-porous	Column	£1,374.69

Features

Specifically designed for drug-to-antibody conjugates (ADCs) and antibodies
Ideal drug-to-antibody ratio (DAR) analysis
High throughput by reducing analysis time
Excellent batch-to-batch reproducibility
Long term stability

Specifications

	BioPro HIC HT	BioPro HIC BF
Base Particle	Hydrophilic polymer (polymethacrylate)	Hydrophilic polymer (polymethacrylate)
Functional Group	Butyl	Butyl
Particle Size	2.3 µm	4 µm
Pore Size	Non-porous	Non-porous
Temperature Range	10 – 60°C	10 – 60°C
pH Range	2 – 12	2 – 12
Pressure Limit	400 bar	200 bar

Literature

YMC Biochromatography Columns Catalogue (11.43 MB)

Overview of YMC's range of columns for biochromatography

YMC Phase Overview BioLC (2.12 MB)

Stationary phases for Bio LC from YMC