YMC BioPro IEX Resin
All pictures shown are for illustration purpose only. Actual product may vary.
BioPro IEX resins are ion exchange chromatography media designed for the analysis and purification of a broad range of biomolecules, including proteins, antibodies, peptides and oligonucleotides. Available as strong anion (Q) and strong cation (S) exchangers, the range supports multiple stages of downstream processing, from initial capture through to intermediate purification and final polishing. High dynamic binding capacity, particularly in larger particle size variants, enables efficient target capture with high loadability, while smaller particle sizes are suited to later stages where enhanced resolution is required.
The BioPro IEX and BioPro IEX SmartSep ranges are designed to provide consistent chromatographic performance across particle sizes, supporting straightforward scale-up without changes in separation behaviour. Their pressure–flow characteristics allow operation at elevated flow rates with low backpressure, while maintaining separation efficiency. Compatibility with alkaline cleaning-in-place (CIP) protocols enables effective removal of contaminants, contributing to process robustness, operational safety and extended resin lifetime across repeated use.
Features
- Suitable for Smaller and Mid-Sized Biomolecule Types – Ideal choice for purification of proteins, antibodies, peptides and oligonucleotides
- Optimised for All Purification Stages – Enables use from initial capture through intermediate purification to final polishing
- High Dynamic Binding Capacity – Supports efficient capture and high loadability at elevated flow rates
- High Resolution Options (SmartSep) – Smaller particle sizes support improved separation during polishing steps
- Scalable Across Particle Sizes – Maintains consistent chromatographic behaviour from development to production scale
- Low Backpressure Operation – Enables use at higher flow rates without excessive pressure
- Alkaline CIP Compatibility – Facilitates effective cleaning, improved process safety and extended resin lifetime
- Range of Pack Sizes Available – Offered in volumes from 50 mL up to 20 L; please contact us for pricing and availability
Specification
BioPro AEX Resins
| BioPro IEX SmartSep Q10 | BioPro IEX SmartSep Q20 | BioPro IEX SmartSep Q30 | BioPro IEX Q75 | |
| Ion Exchange Type | Strong Anion Exchanger | Strong Anion Exchanger | Strong Anion Exchanger | Strong Anion Exchanger |
| Charged Group | -R-N+(CH3)3 | -R-N+(CH3)3 | -R-N+(CH3)3 | -R-N+(CH3)3 |
| Base Material | Hydrophilic polymethacrylate beads | Hydrophilic polymethacrylate beads | Hydrophilic polymethacrylate beads | Hydrophilic polymethacrylate beads |
| Particle Size | 10 µm | 20 µm | 30 µm | 75 µm |
| Pore Size | Porous | Porous | Porous | Porous |
| pH Range | 2.0 - 12.0 (compatible with 1 M NaOH for CIP) | 2.0 - 12.0 (compatible with 1 M NaOH for CIP) | 2.0 - 12.0 (compatible with 1 M NaOH for CIP) | 2.0 - 12.0 (compatible with 1 M NaOH for CIP) |
| Ion Exchange Capacity | minimum 0.08 meq/mL resin | minimum 0.08 meq/mL resin | minimum 0.08 meq/mL resin | minimum 0.10 meq/mL resin |
| Dynamic Binding Capacity | minimum 100 mg/mL resin (BSA) | minimum 100 mg/mL resin (BSA) | minimum 100 mg/mL resin (BSA) | minimum 160 mg/mL resin (BSA) |
| Compression Factor | 1.05-1.15 | 1.05-1.15 | 1.05-1.15 | 1.05-1.15 |
| Typical Flow Rate | 200-1000 cm/h, maximum 2000 cm/h | 200-1000 cm/h, maximum 2000 cm/h | 200-1000 cm/h, maximum 2000 cm/h | 200-1000 cm/h, maximum 2000 cm/h |
| Pressure Limit | 4 MPa | 3 MPa | 3 MPa | 0.3 MPa |
BioPro CEX Resins
| BioPro IEX SmartSep S10 | BioPro IEX SmartSep S20 | BioPro IEX SmartSep S30 | BioPro IEX S75 | |
| Ion Exchange Type | Strong Cation Exchanger | Strong Cation Exchanger | Strong Cation Exchanger | Strong Cation Exchanger |
| Charged Group | -R-SO3- | -R-SO3- | -R-SO3- | -R-SO3- |
| Base Material | Hydrophilic polymer beads | Hydrophilic polymer beads | Hydrophilic polymer beads | Hydrophilic polymer beads |
| Particle Size | 10 µm | 20 µm | 30 µm | 75 µm |
| Pore Size | Porous | Porous | Porous | Porous |
| pH Range | 2.0 - 12.0 (compatible with 1 M NaOH for CIP) | 2.0 - 12.0 (compatible with 1 M NaOH for CIP) | 2.0 - 12.0 (compatible with 1 M NaOH for CIP) | 2.0 - 12.0 (compatible with 1 M NaOH for CIP) |
| Ion Exchange Capacity | minimum 0.08 meq/mL resin | minimum 0.08 meq/mL resin | minimum 0.08 meq/mL resin | minimum 0.10 meq/mL resin |
| Dynamic Binding Capacity | minimum 100 mg/mL resin (Lysozyme) | minimum 100 mg/mL resin (Lysozyme) | minimum 100 mg/mL resin (Lysozyme) | minimum 160 mg/mL resin (Lysozyme) |
| Compression Factor | 1.05-1.15 | 1.05-1.15 | 1.05-1.15 | 1.05-1.15 |
| Typical Flow Rate | 200-1000 cm/h, maximum 2000 cm/h | 200-1000 cm/h, maximum 2000 cm/h | 200-1000 cm/h, maximum 2000 cm/h | 200-1000 cm/h, maximum 2000 cm/h |
| Pressure Limit | 4 MPa | 3 MPa | 3 MPa | 0.3 MPa |
