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Advion-Interchim puriFlash 5.050

The puriFlash 5.050 from Advion-Interchim Scientific is a versatile chromatography system designed to accommodate both flash and preparative purification workflows within a single platform. Designed for laboratories seeking high-performance separations, it supports transitions between normal phase and reversed phase chromatography, including compatibility with reusable stainless-steel columns packed with low-particle-size media – enabling higher resolution and improved compound purity.

With a maximum operating pressure of 50 bar, the system is well suited for more demanding preparative tasks while maintaining the rapid throughput and ease of flash chromatography. Integrated wash disc technology enhances instrument longevity by enabling back-flushing of pump heads with water, which reduces the risk of crystallisation from mobile phase additives – a common issue in routine purifications.

The puriFlash 5.050 incorporates multiple detection modes, including UV, ELSD, and mass detection, to ensure accurate compound tracking and improved recovery, particularly when working with complex mixtures. Advanced safety features, such as solvent level sensors and leak detection, protect both user and system from operational errors and equipment wear.

Control and data handling are streamlined through the ClearPeak software on a 15 inch touchscreen, enabling real-time monitoring, simplified method development, and automatic consumable recognition via RFID. The integrated Genius interface supports AI-assisted method creation, including TLC-to-method conversion, improving efficiency and reproducibility. With remote monitoring and mobile app support, users can oversee purifications from anywhere. Compact yet highly capable, the puriFlash 5.050 is well suited for both routine and advanced chromatographic applications.

Features

  • ClearPeak Software Control – Full system management with intuitive interface for method development, monitoring, and automation
  • 15" Touchscreen & Remote Monitoring – Real-time control with remote access for flexible workflow management
  • Smartphone App Integration – Compatible with TLC to Flash & Prep app for seamless method transfer from TLC plates
  • Multi-Wavelength UV Detection – 200–400 nm range with simultaneous multi-wavelength and collective scanning
  • Column Compatibility – Supports flash columns (F0004 to F3000) and preparative columns up to 80 mm (3") internal diameter
  • High Capacity Racks – Includes 3 long racks with space for up to 132 test tubes
  • High Flow Rate – Up to 250 ml/min for rapid processing of large sample volumes
  • High Pressure Capability – Operates up to 50 bar for efficient preparative and reversed phase chromatography
  • Performance Upgrade Packs – Optional UVextended and iELSD modules available for enhanced detection sensitivity and compound coverage

Specification

  puriFlash 5.050
Pump  
Flow rate 250 mL/min
Max pressure 50 bar
Quaternary gradient yes
Air purge yes
Washing discs yes
Pump washing discs (pack) no
   
Detector  
UV: 200 - 400 nm multi wavelength & scan collection yes
UV: 200 - 800 nm multi wavelength & scan collection pack-UVextended
Spectral view and purity confirmation yes
iELSD Detection (pack) pack-iELSD
   
Injection  
4 port electrical valve no
6 port electrical valve with loop yes
6 port + 10 port electrical valves with loop no
Injection mode: liquid - dry-load yes
   
Column Selection Valve  
6 port electrical valve no
   
System Optimisation  
Tubing after pump 1/8" x 1.6 mm ID
Flow cell: optical length/volume 0.3 mm/40 µL
   
Column Holder  
Integrated yes
Pre-column holder yes
   
Fraction Collector  
Reglular collector 3 racks Gen5
132 tubes 18 x 150 mm
   
Unit Control  
Touch screen 15" yes
USB 8
RJ45 yes
   
Safety  
Leak detection (pump, FC, iELSD, holders) yes
Solvent tray with drainage system yes
Collector with drainage system yes
Solvent and waste level monitoring yes
RFID yes
Fume enclosure yes
   
Size Width: 40 cm
Depth: 51 cm
Height: 75 cm

Literature

The essential systems and consumables for purification, evaporation, and mass spectrometry

Videos