Bio-inert Supplies

Analysis of proteins and biotherapeutics usually presents the most challenging solvent conditions for any LC instrument. In addition, bio-molecules tend to bind unspecifically to surfaces, requiring tedious procedures. To address these needs LC systems have been designed with bio-inertness for all components. The sample flow path through the autosampler, capillaries and a variety of detectors are completely metal-free, with only PEEK and ceramic components coming into contact with your bio-molecule. Thus, the uncertainty of secondary interaction for proteins and peptides with surfaces which can result in peak tailing, low recovery and decreased column lifetime is minimized.

Bio-inert HPLC supplies are designed to minimise unwanted interactions between sensitive analytes and the chromatographic flow path, helping to improve recovery, peak shape, and reproducibility. Bio-inert parts are particularly important for biological and metal-sensitive compounds such as proteins, peptides, oligonucleotides, phosphopeptides, and biotherapeutics, where contact with standard metal surfaces can lead to adsorption, sample loss, peak tailing, or reduced sensitivity. 

A typical range of bio-inert HPLC supplies includes capillaries, fittings, valves, needle seats, pump seals, and detector flow cells manufactured from bio-inert materials such as PEEK, titanium, ceramic, or specialist inert coatings. Used alongside bio-inert HPLC columns, these components create a more compatible flow path for challenging samples, helping to reduce secondary interactions, support more accurate quantitation, and maintain reliable chromatographic performance across biomolecule and biopharmaceutical workflows.