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Solvent Reservoir Filters from Agilent

Agilent provides a range of solvent filters for use with a variety of LC applications and equipment. Glass filters and solvent inlets with 20 µm pore sizes can be utilized for analytical scale and micro scale LC and a 40 µm pore size for preparative LC or dual loop autosamplers. Stainless steel solvent inlet filters are also available for use in capillary and nano systems.

All solvent filters and frit adapters are manufactured to Agilent's high levels of quality and security.

Part Number Short Description Porosity Type Pack Size Price Qty
5062-8517 Frit Adapter, 3mm, PTFE, 4pk Frit Adapter 4
G1361-23204 Frit Adapter, 4mm, PTFE, 1pk Frit Adapter 1
G2258-23201 Frit Adapter, PTFE, for 1/8in OD Tubing to 6mm ID Inlet Frit Frit Adapter 1
G1361-23205 Frit Adapter, PTFE, for 4.7mm od Tubing Frit Adapter 1
5041-2168 Glass Filter, Solvent Inlet, 20um 20 um Solvent Filter 1
3150-0944 Glass Filter, Solvent Inlet, 40um 40 um Solvent Filter 1
5023-3115 Solvent Inlet Filter, 20um, 2pk 20 um Solvent Filter 2
01018-60025 Stainless Steel Filter, Solvent Inlet, 10um 10 um Solvent Filter 1

Solvent Filters

Solvent inlet filters represent the first barrier for retaining particulates, precipitation, microbes from mobile phases, buffers, and salt solutions. Filters are significant in preventing system blockage, pressure increase, and contamination. Cleanliness of parts is vital for avoiding system contamination. Agilent solvent filters are packed in ultraclean antistatic bags with an inner metallic coating that does not release contaminants such as plasticizers or antioxidants. LC/MS analysis shows that filters not from Agilent, packed in normal plastic packs, can cause extra peaks during analysis. Erucamide, a common slip agent used in polyethylene films, is one such example.

Pore size

A good solvent glass filter should have a defined, homogenous pore size to effectively block particulates above a certain size, while letting mobile phases through without significant pressure increase. Too large pore size leads to deficiency of filtration, while pores that are too small can cause pressure increase, resulting in solvent pumping difficulties. Inspection of Agilent and other vendor solvent glass filters by scanning electron microscopy (SEM) shows uniform pore sizes and smooth particle surfaces in the Agilent filter. In contrast, other vendor filters had inconsistent particle and pore sizes. The small particles or particle fragments shown on the other vendor filter could be flushed into the flow path, blocking the pump frit, capillaries, valves, or columns.

Cleaning the Solvent Filter

If the filter is in good condition, the solvent will freely drip out of the solvent tube (hydrostatic pressure). If the solvent filter is partially blocked, only very little solvent will drip out of the solvent tube. Caution: Small particles can permanently block the capillaries and valves of the module.

  • Always filter solvents
  • Never use the module without solvent inlet filter
Description Recommended Use Part Number Frit Adapter Part Number Frit Inlet ID (mm) Tube OD (mm)
Glass filter, solvent inlet, 20 µm pore size Analytical scale, micro scale 5041-2168  Frit adapter, PTFE, 3 mm, 4/pk  5062-8517 5 3.2
Stainless steel filter, solvent inlet, 10 µm pore size For use in capillary and nano systems 01018-60025 No adapter required, filter goes directly into 1.5 mm id tubing      
Glass filter, solvent inlet, 40 µm pore size Preparative LC 3150-0944  Frit adapter, PTFE, for 4.7 mm od tubing G1361-23205 7 4.7
Glass filter, solvent inlet, 40 µm pore size Preparative LC 3150-0944  Frit adapter, PTFE, 4 mm G1361-23204 7 4
Glass filter, solvent inlet, 40 µm pore size For G2258A dual loop autosampler 3150-0944 Frit adapter, PTFE, for 3.2 mm od tubing G2258-23201 7 3.2
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