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Supported Liquid Extraction (SLE)

Solid supported liquid/liquid (SLE) extraction is a fast effective sample preparation techniques that provides considerable benefits over liquid/liquid extraction (LLE) protocols for removal of phospholipids from biological samples.

SLE offers the following advantages:

  • Greater recoveries and reproducibility compared to LLE
  • Prevents emulsification as the sample and water immiscible solvent do not directly mix
  • Reduced solvent requirements compared to LLE
  • Can be completely automated
  • Improved sample cleanliness and sensitivity compared to protein precipitation techniques

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