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Mixed-Mode HPLC Columns

Mixed-mode HPLC columns combine reversed phase, ion-exchange, and/or HILIC selectivity and are designed for the separation of ionic and hydrophobic analytes in a single run. They eliminate the need for column switching, ion-paring, and using columns in series. Selectivity can be easily optimised by adjusting mobile phase buffer concentration, pH, and solvent content to improve chromatographic separations and increase productivity.

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