Agilent AdvanceBio RP-mAb Columns

AdvanceBio RP-mAb HPLC Columns from Agilent

Analysis of intact and reduced monoclonal antibodies are critical measurements for characterizing therapeutic proteins and understanding their efficacy and stability. Poor chromatographic separations can result in rework and even compromise the accuracy of the characterization.

Based on Poroshell technology with unique engineering for pore size and bonded phases, AdvanceBio RP-mAb columns deliver higher resolution and faster run times to provide accurate, reproducible results. Available in a range of chemistries – SB-C8, C4, and diphenyl.

Agilent AdvanceBio RP-mAb columns are designed to optimize the performance of intact and reduced mAb analysis when analyzing monoclonal antibodies for biopharma discovery, development, and QA/QC applications. Analysis of intact and reduced monoclonal antibodies are critical measurements for characterizing therapeutic proteins and understanding their efficacy and stability. Poor chromatographic separations can result in rework and even compromise the accuracy of the characterization.

Based on Poroshell technology with unique engineering for pore size and bonded phases, AdvanceBio RP-mAb columns deliver higher resolution and faster run times to provide accurate, reproducible analysis and results. These RP-mAb columns are available in a range of chemistries – SB-C8, C4, and diphenyl.

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Part Number	Short Description	Phase	Particle Size	ID	Length	Pore Size	Type	Price
795775-904	AdvanceBio RP-mAb C4 2.1 x 100mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	2.1 mm	100 mm	450 A	Column	£760.00
793775-904	AdvanceBio RP-mAb C4 2.1 x 150mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	2.1 mm	150 mm	450 A	Column	£828.00
799775-904	AdvanceBio RP-mAb C4 2.1 x 50mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	2.1 mm	50 mm	450 A	Column	£599.00
797775-904	AdvanceBio RP-mAb C4 2.1 x 75mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	2.1 mm	75 mm	450 A	Column	£681.00
795975-904	AdvanceBio RP-mAb C4 4.6 x 100mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	4.6 mm	100 mm	450 A	Column	£760.00
793975-904	AdvanceBio RP-mAb C4 4.6 x 150mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	4.6 mm	150 mm	450 A	Column	£828.00
799975-904	AdvanceBio RP-mAb C4 4.6 x 50mm 3.5um Column	AdvanceBio RP-mAb C4	3.5 um	4.6 mm	50 mm	450 A	Column	£595.00
795775-944	AdvanceBio RP-mAb Diphenyl 2.1 x 100mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	2.1 mm	100 mm	450 A	Column	£760.00
793775-944	AdvanceBio RP-mAb Diphenyl 2.1 x 150mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	2.1 mm	150 mm	450 A	Column	£828.00
799775-944	AdvanceBio RP-mAb Diphenyl 2.1 x 50mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	2.1 mm	50 mm	450 A	Column	£599.00
797775-944	AdvanceBio RP-mAb Diphenyl 2.1 x 75mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	2.1 mm	75 mm	450 A	Column	£681.00
795975-944	AdvanceBio RP-mAb Diphenyl 4.6 x 100mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	4.6 mm	100 mm	450 A	Column	£760.00
793975-944	AdvanceBio RP-mAb Diphenyl 4.6 x 150mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	4.6 mm	150 mm	450 A	Column	£828.00
799975-944	AdvanceBio RP-mAb Diphenyl 4.6 x 50mm 3.5um Column	AdvanceBio RP-mAb Diphenyl	3.5 um	4.6 mm	50 mm	450 A	Column	£595.00
785775-906	AdvanceBio RP-mAb SB-C8 2.1 x 100mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	2.1 mm	100 mm	450 A	Column	£760.00
783775-906	AdvanceBio RP-mAb SB-C8 2.1 x 150mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	2.1 mm	150 mm	450 A	Column	£828.00
789775-906	AdvanceBio RP-mAb SB-C8 2.1 x 50mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	2.1 mm	50 mm	450 A	Column	£599.00
787775-906	AdvanceBio RP-mAb SB-C8 2.1 x 75mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	2.1 mm	75 mm	450 A	Column	£681.00
785975-906	AdvanceBio RP-mAb SB-C8 4.6 x 100mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	4.6 mm	100 mm	450 A	Column	£760.00
783975-906	AdvanceBio RP-mAb SB-C8 4.6 x 150mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	4.6 mm	150 mm	450 A	Column	£828.00
789975-906	AdvanceBio RP-mAb SB-C8 4.6 x 50mm 3.5um Column	AdvanceBio RP-mAb SB-C8	3.5 um	4.6 mm	50 mm	450 A	Column	£595.00

Features

3.5 µm superficially porous particles with 450 Å wide pores increase mAb resolution while maintaining compatibility with all LC instruments
Shorter analysis times compared to columns packed with fully porous particles of the same size
Robust Poroshell packed bed and 2 µm inlet frit extend column lifetime by helping prevent inlet blockage
Flexible method development with range of chemistries including SB-C8, C4, and diphenyl

Specifications

	AdvanceBio RP-mAb C4	AdvanceBio RP-mAb SB-C8	AdvanceBio RP-mAb Diphenyl
Bonded Phase	C4	SB-C8	Diphenyl
Particle Type	Superficially Porous	Superficially Porous	Superficially Porous
Particle Size	3.5 µm	3.5 µm	3.5 µm
Pore Size	450 Å	450 Å	450 Å
Temperature Limit	90°C	90°C	90°C
pH range	1 - 8	1 - 8	1 - 8
Pressure Limit	600 bar	600 bar	600 bar

Literature

Agilent AdvanceBio RP-mAb columns brochure (1.18 MB)

Resolve mAbs faster and better with Agilent AdvanceBio RP-mAb columns

Intact and Subunit Purity Application Compendium (3.08 MB)

Collection of Agilent app notes for intact and subunit analysis

AdvanceBio Reversed Phase Columns White Paper (3.07 MB)

Better characterization of biomolecules using Agilent AdvanceBio reversed phase columns

Agilent Bio HPLC Columns (26.00 MB)

Your essential resource for biomolecule analysis