Supercritical fluid chromatography (SFC) is similar to liquid chromatography; however it utilizes extreme conditions of temperature and pressure so that the mobile phase (typically carbon dioxide) remains as a supercritical fluid. This results in fast and high efficiency separations due to the lower viscosity and larger diffusion coefficients for the supercritical fluid. Use of liquid carbon dioxide is also considered a green technology as there is limited organic solvent waste.
Crawford Scientific offer a wide range of dedicated chiral and achiral columns for Supercritical Fluid Chromatography. We can supply SFC columns from premium manufacturers such as Daicel and YMC to cover a wide variety of application areas.
Daicel SFC columns are available in a range of immobilized or coated chiral stationary phases in analytical, semi-preparative and preparative dimensions for the purification of enantiomers.
YMC Alycon SFC columns are available in both chiral and achiral stationary phases. The achiral range includes C18, Diol, PFP, CN and SIL stationary phases and is an alternative to purification by classical HPLC.