Analysis of proteins and biotherapeutics usually presents the most challenging solvent conditions for any LC instrument. In addition, bio-molecules tend to bind unspecifically to surfaces, requiring tedious procedures. To address these needs LC systems have been designed with bio-inertness for all components. The sample flow path through the autosampler, capillaries and a variety of detectors are completely metal-free, with only PEEK and ceramic components coming into contact with your bio-molecule. Thus, the uncertainty of secondary interaction for proteins and peptides with surfaces which can result in peak tailing, low recovery and decreased column lifetime is minimized.