Thermo Scientific Acclaim Trinity P1 HPLC Columns

Thermo Scientific Acclaim Trinity P1 HPLC columns have a unique trimodal surface chemistry which provides concurrent reversed phase, cation-exchange, and anion-exchange functionalities for maximum flexibility in method development. Selectivity can be easily optimised by adjusting mobile phase buffer concentration, pH and solvent content - either jointly or independently - to accelerate chromatographic separations and increase productivity. The Acclaim Trinity P1 is ideal for the simultaneous separation of pharmaceutical drug substances and their counterions on one column.

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Part Number	Short Description	Phase Type	Phase	Particle Size	ID	Length	Pore Size	Type	Price
071387	Acclaim Trinity P1, 3um, 3 x 100mm	Mixed-Mode	Acclaim Trinity P1	3 um	3.0 mm	100 mm	300 A	Column	£752.61
071388	Acclaim Trinity P1, 3um, 3 x 50mm	Mixed-Mode	Acclaim Trinity P1	3 um	3.0 mm	50 mm	300 A	Column	£585.49
071389	Acclaim Trinity P1, 3um, 2.1 x 100mm	Mixed-Mode	Acclaim Trinity P1	3 um	2.1 mm	100 mm	300 A	Column	£752.61
071390	Acclaim Trinity P1, 3um, 3 x 10mm, Guard Cartridge, 2pk	Mixed-Mode	Acclaim Trinity P1	3 um	3.0 mm	10 mm	300 A	Guard	£162.45
071391	Acclaim Trinity P1, 3um, 2.1 x 10mm, Guard Cartridge, 2pk	Mixed-Mode	Acclaim Trinity P1	3 um	2.1 mm	10 mm	300 A	Guard	£160.91
075563	Acclaim Trinity P1, 3um, 3 x 150mm	Mixed-Mode	Acclaim Trinity P1	3 um	3.0 mm	150 mm	300 A	Column	£767.80
075564	Acclaim Trinity P1, 3um, 2.1 x 150mm	Mixed-Mode	Acclaim Trinity P1	3 um	2.1 mm	150 mm	300 A	Column	£767.80
075565	Acclaim Trinity P1, 3um, 2.1 x 50mm	Mixed-Mode	Acclaim Trinity P1	3 um	2.1 mm	50 mm	300 A	Column	£585.49

Features

Mixed-mode column technology combining reversed-phase, anion exchange, and cation exchange
Inner-pore is bonded with a bi-modal reversed-phase and anion-exchange functionality, and the outer surface is modified with cation-exchange nano-polymer beads
Ideal selectivity for simultaneous separation of Active Pharmaceutical Ingredients (API) and counterions (basic, neutral, and acidic analytes)
Effective retention of hydrophilic ionic and ionizable analytes without ion-pairing reagents
Distinctive spatial separation of the anion-exchange and cation-exchange regions
Flexible method development with each retention mechanism controlled independently
Low column bleed: compatible with mass spectrometry (MS), charged aerosol detection (CAD) and evaporative light scattering detectors (ELSD)
Use alongside the Acclaim Trinity P2 to provide a total solution for pharmaceutical couterion analysis by HPLC

Specifications

	Acclaim Trinity P1
Mode	Mixed-Mode
Phase Type	Trimode phase containing SCX, WAX and reversed phase functionalities
Particle Type	Fully Porous
Particle Size	3 µm
Pore Size	300 Å
Surface Area	100 m²/g
Temperature Limit	45°C
pH Limit	2.5 - 7.0
Pressure Limit	310 bar

Literature

Analytical UHPLC and HPLC Columns Brochure (11.02 MB)

Introduction to the broad range of chemistries and column families from Thermo Scientific

Acclaim Mixed-Mode Brochure (5.52 MB)

Columns for challenging separation needs

Acclaim Trinity P1 Product Specifications (578.62 kB)

Superior pharmaceutical and counterion separations

Acclaim Trinity P1 Column Manual (1.64 MB)

User guide for the Acclaim Trinity P1 columns

Acclaim Column Selection Guide (96.31 kB)

Quick guide to choosing your Acclaim phase by application