Ion Exchange Columns

Ion-exchange chromatography (IEX) is a highly sensitive technique that allows you to separate ions and polar molecules based on their charge.

During production and purification, antibodies can exhibit changes in charge heterogeneity because of amino acid substitutions, glycosylation, phosphorylation, and other post-translational or chemical modifications. Because these changes can impact stability and activity - or cause immunologically adverse reactions - the analysis of charge heterogeneity in monoclonal antibody (mAb) preparations is critical to biopharmaceutical manufacture.

During production and purification, antibodies can exhibit changes in charge heterogeneity because of amino acid substitutions, glycosylation, phosphorylation, and other post-translational or chemical modifications. Because these changes can impact stability and activity - or cause immunologically adverse reactions - the analysis of charge heterogeneity in monoclonal antibody (mAb) preparations is critical to biopharmaceutical manufacture.

Because these changes can impact stability and activity - or cause immunologically adverse reactions - the analysis of charge variants is critical to biopharmaceuticals.